CB1 receptors are found primarily in the brain, more specifically in the basal ganglia and in the limbic-system, including the hippocampus.
CB2 receptors are predominantly found in the immune system, with the greatest density in the spleen. CB2 receptors appear to be responsible for the anti-inflammantory and possibly other therapeutic effects of CBD dog treats seen in cannabis animal food products.
You’ll find the receptors in every part of the body, even though you’ll find more in certain areas. There are two different types of receptors, named CB1 and CB2. They’re defined and distinguished by the signaling mechanisms that they use to activate. So for example, you may have both kinds of receptors in your peripheral nervous system (the nerve cells outside the brain or spinal cord.) However, since the CB2 receptors are stronger in the peripheral nervous system, it’s those that will matter when it comes to your body’s reaction. Understanding the difference gives you a better indication of how you should be using cannabis.
We’ll give you a brief overview of which systems are most heavily affected by CB1 and CB2 receptors and how, though keep in mind that every system can be affected. You should talk to a medical professional about your particular condition to find out more about dosages and kinds of cannabis to use.
Central Nervous System: For those who suffer from anxiety, PTSD, or other mood disorders, the central nervous system primarily has CB1 receptors. It has been shown that cannabinoids will bind to the amygdala(the part of the brain responsible for emotions) and make the neurons in the brain far less active.
Immune and GI Systems: For those who suffer from autoimmune diseases or digestive issues, it’s the CB2 receptors that will determine how the body feels and how it responds to the condition. Researchers have seen that CB2 is often used to help animals and humans cope with unexpected injury, or general pain and inflammation.
You’ll find both CB receptors in the brain, though the concentration of CB1 receptors is much higher than CB2. There are two major components of cannabis: THC and CBD. THC generally activates CB1 receptors, while CBD activates CB2 receptors. The presence of CB1 receptors in the brain partially explains why THC produces psychoactive effects in the brain, while CBD does not.
Recently, the CB2 receptor has shown that it is found in neurons as well. Scientists still debate whether these receptors are found in the brain.
After taking Beta Caryophyllene, I believe it is found in the brain.
CB2 receptors are found throughout tissues of the immune system, including the spleen, tonsils, and thymus gland, where they are primarily responsible for inhibiting cytokine release. CB2 receptors are found on immune cells such as monocytes, macrophages, B-cells, and T-cells.
In the brain, CB2 receptors are found primarily on microglia, which are the immune cells of the brain, as well as the hypothalamus, striatum, amygdala, prefrontal cortex, brainstem, VTA, basal ganglia, and hippocampus to a lesser extent.
CB2 receptors are also found throughout the gut, where they inhibit intestinal inflammatory response.
The CB2 receptor is a potential therapy for inflammatory bowel diseases, such as Crones Disease.
The CB2 receptor is found on mast cells and can inhibit mast cell release
CB2 receptor activators cause a reduction in, which results in a reduction in the binding of transcription factor response element-binding protein) to DNA. This reduction causes changes in gene expression and ultimately suppression of immune function (inhibition of T cell activation)